On-demand Webinar
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1 CME Credit
Grey matter atrophy in MS. Is it a solution for clinico-radiological paradox?
Grey matter and regional brain atrophy are examined as potential MRI biomarkers in multiple sclerosis.
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Description
The limited correlation between conventional lesion burden and clinical outcome provides the basis for evaluating brain atrophy as an alternative marker. Measurement methods, biological mechanisms, regional variation, clinical-trial use, iron-rim lesions, other emerging biomarkers, and current limitations are reviewed.
Learning Objectives
- Explain the clinico-radiological paradox and limitations of conventional lesion burden in multiple sclerosis.
- Describe methods and biological factors involved in measuring global and regional brain atrophy.
- Evaluate the potential and limitations of atrophy and emerging MRI biomarkers for prognosis and research.
Topics Covered
To jump to a specific chapter, click on the chapter title once the video is playing.
00:00 - Introduction and Background
00:39 - Significance of Multiple Sclerosis Research
01:57 - Focus on Atrophy in MS
02:57 - Importance of Imaging Biomarkers
04:39 - Challenges with Current MS Measurements
06:01 - Introduction of Atrophy as a Biomarker
07:49 - Use of Atrophy in MS Clinical Trials
09:18 - Measuring Atrophy in MS Patients
10:52 - Biology Behind Atrophy in MS
12:14 - Variation of Atrophy Across Brain Regions
13:43 - Potential New Biomarkers for MS
15:09 - Significance of Iron Rim Lesions and Other Possible Biomarkers
16:56 - Challenges and Future Directions in MS Imaging
Lecturers
Zsigmond Tamás KincsesM.D. Ph.D.
Szeged, Hungary
Director of the Department of Radiology, University of Szeged, Hungary
Director of the Department of Radiology, University of Szeged. Radiologist, with a special interest of neuroradiology and neuroimaging. Consultant neurologist at the Department of Neurology, University of Szeged. MS specialist in the largest MS centre in Hungary. PhD from University of Göttingen, Germany and post-doc in FMRIB Center, University of Oxford. Expert of advanced neuroimaging approaches. Nearly 100 peer-reviewed articles, in the field of multiple sclerosis, primary headache disorders and neurodegenerative diseases.
