On-demand Webinar
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0.5 CME Credits
Bilateral/Symmetric Deep GM Lesions
Bilateral and symmetrical deep grey matter lesions are differentiated through a pattern-based diagnostic approach.
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Description
Basal ganglia and thalamic anatomy are integrated with acuity, distribution, and clinical context across hypoxic, toxic, metabolic, infectious, inflammatory, vascular, and neoplastic disease. Examples include carbon monoxide poisoning, Wilson and Leigh diseases, Wernicke encephalopathy, autoimmune encephalitis, artery of Percheron infarction, and bilateral thalamic glioma.
Learning Objectives
- Localise abnormalities within the basal ganglia and thalami and assess their symmetry and time course.
- Differentiate hypoxic, toxic, and metabolic causes of deep grey matter lesions.
- Recognise infectious, inflammatory, vascular, and neoplastic patterns that enter the differential diagnosis.
- Recognise characteristic patterns in Wilson disease, Leigh disease, Wernicke encephalopathy, and carbon monoxide poisoning.
- Differentiate artery of Percheron infarction, bilateral thalamic glioma, and opportunistic infection.
Topics Covered
To jump to a specific chapter, click on the chapter title once the video is playing.
00:00 - Introduction to Deep Gray Matter Lesions
00:33 - Anatomy of the Basal Ganglia and Deep Gray Matter
01:05 - Symptoms and Clinical Presentation of Lesions
01:50 - Differential Diagnosis of Deep Gray Matter Lesions
03:18 - Acute and Chronic Lesions: Imaging and Etiologies
06:11 - Imaging Features: Creutzfeldt-Jakob Disease
08:59 - Hypoxic Ischemic Injury and Anoxia in Different Age Groups
10:19 - Kernicterus and Bilirubin Encephalopathy
12:47 - Metabolic and Toxic Lesions: Chronic Hepatic Encephalopathy
14:42 - Carbon Monoxide Poisoning: Imaging and Clinical Features
17:10 - Metabolic Acidosis and Toxic Encephalopathies
20:19 - Wilson's Disease and Other Metabolic Disorders
22:08 - Leigh Disease: Imaging Characteristics
23:35 - Wernicke Encephalopathy: Causes and Imaging
25:50 - Autoimmune Encephalitis and ADEM
28:06 - Differentiating Brain Tumors: Bilateral Thalamic Gliomas
31:01 - Infarctions in the Artery of Percheron
34:24 - Cryptococcus Infection in Immunocompromised Patients
40:39 - Summary and Overview of Deep Gray Matter Lesions
46:00 - Q&A: Reviewing Clinical and Imaging Scenarios
Lecturers
Zoran RumboldtM.D. Ph.D.
Rovinj-Rovigno, Croatia
Consultant neuroradiologist at TMC; Professor of Radiology at University of Rijeka, Croatia; Adjunct Professor of Radiology at MUSC, Charleston, SC, USA
Over 20 years of experience in neuroradiology, previously Neuroradiology Section Chief and Fellowship Program Director at MUSC, Charleston, USA. Invited speaker at major meetings (RSNA, ECR, ARRS, ASNR, ESNR) from 2005, visiting professor on four continents from 2008, lecturer at various courses from 2013, including ECNR. Over 100 peer-reviewed articles; editor of books Brain Imaging with MRI and CT & Clinical Imaging of Spine Trauma; over 30 review articles and book chapters; awards for teaching since 2004.
