Tumour response to treatment: RECIST and beyond

RECIST 1.1 and alternative criteria provide an objective framework for imaging assessment of tumour response to modern therapies.

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Overview

Description

Response assessment is traced from WHO criteria to RECIST 1.1, including baseline, nadir, measurable disease, target lesions, and response categories. Limitations in anti-angiogenic and immune therapies, pseudoprogression, modified criteria, iRECIST, and potential roles for advanced imaging are examined.

Learning Objectives

Apply RECIST 1.1 definitions for measurable disease, target lesions, baseline, and nadir.
Categorise treatment response and recognise limitations of size-based assessment.
Explain when modified or immune-response criteria and advanced imaging may be appropriate.
Recognise pseudoprogression and atypical response patterns associated with anti-angiogenic and immune therapies.

Topics Covered

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00:17 - Introduction to Tumor Evaluation by Imaging

00:48 - Objective Tumor Evaluation Importance

01:58 - WHO Criteria for Tumor Evaluation

04:52 - Introduction of RACIST Criteria

06:28 - RACIST 1.1 and Modified RACIST

07:37 - Defining Baseline and Nadir Sizes

09:46 - Measurable vs. Non-measurable Lesions

12:28 - Target Lesions in RACIST Criteria

17:02 - Evaluating Therapeutic Response

25:10 - Limitations of RACIST Criteria

30:45 - Anti-Angiogenic Treatments and Pseudo-Progression

36:32 - Alternative Response Evaluation Criteria

40:06 - Immune RACIST Evaluation System

47:00 - When to Use iRACIST

51:08 - Advanced Imaging and Future Prospects

Lecturers

András Palkó^{M.D. Ph.D.}

Szeged, Hungary

Consultant radiologist at TMC and professor of Radiology at University of Szeged, Hungary

Professor András Palkó, M.D, Ph. D. has extensive clinical as well as academic experience. Dr. Palkó has been working with abdominal CT and MRI for 25 years. He is the author of 90 peer reviewed papers and over 40 books and book chapters, invited speaker of international scientific and educational conferences, co-founder and faculty member of the European School of Radiology and examiner for the European Diploma in Radiology

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